Effects of combined administration of vitamins C and E on some Plasmodium berghei-induced pathological changes and oxidative stress in mice
| Autor: | Musa Bashir, M. Bisalla, Murtala Bindawa Isah, A I Okafor, Mohammed Auwal Ibrahim, I. A. Umar |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Vitamin
Kidney medicine.medical_specialty Antioxidant biology medicine.medical_treatment Spleen biology.organism_classification medicine.disease_cause Pathology and Forensic Medicine Superoxide dismutase chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Catalase Internal medicine Immunology medicine biology.protein Plasmodium berghei Anatomy Oxidative stress |
| Zdroj: | Comparative Clinical Pathology. 21:1677-1682 |
| ISSN: | 1618-565X 1618-5641 |
| DOI: | 10.1007/s00580-011-1348-7 |
| Popis: | This study examined the effects of combined administration of vitamins C and E to Plasmodium berghei-induced anaemia and organ weight alterations as well as changes in endogenous antioxidant status in mice. Three groups of mice were intraperitoneally infected with chloroquine-sensitive P. berghei (NK 65) among which a group was intraperitoneally treated with a combination of vitamins C (100 mg/kg body weight, bw) and E (1,000 i.u./kg bw) whereas another group was treated with chloroquine (25 mg/kg bw). The remaining infected group was left untreated. Data from these groups were compared with those from the uninfected group that was treated with vitamins C and E and the uninfected untreated group. Treatment with vitamins C and E did not significantly (P > 0.05) affect the levels of parasitized red cells for the entire 15-day experimental period except at days 8 and 9 post-infection. At the termination of the experiment, the P. berghei infection was found to induce anaemia, significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink