Aspiration cytologic, ultrastructural, and DNA cytometric findings of solid and papillary tumor of the pancreas
| Autor: | David B. Adams, Mary M.B. Wilson, Paul D. Garen, Ted S. Gansler |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty education.field_of_study Pancreatic disease medicine.diagnostic_test business.industry Population Papillary tumor medicine.disease Neuroendocrine differentiation Flow cytometry medicine.anatomical_structure Oncology Cytology Biopsy Medicine business Pancreas education |
| Zdroj: | Cancer. 69:2235-2243 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19920501)69:9<2235::aid-cncr2820690905>3.0.co;2-p |
| Popis: | Solid and papillary epithelial neoplasm of the pancreas (SPENP) is a rare lesion characteristically occurring in young women. By contrast with pancreatic ductal adenocarcinomas, SPENP is a slow-growing tumor that rarely metastasizes or is fatal. The current report describes light and electron microscopic and histochemical findings with DNA flow cytometric analyses of two cases of SPENP. The first patient was a 24-year-old woman; the second, a 72-year-old man. Although SPENP is rare in older men, both patients had characteristic radiographic and light microscopic features of SPENP. Ultrastructural evidence of acinar differentiation was seen in the first patient; the second patient had focal neuroendocrine differentiation. Flow cytometric analysis of the first tumor demonstrated diploid-range DNA content with a 5.8% S-phase fraction (SPF). The DNA cytometric analysis of a biopsy specimen from the second tumor revealed diploid-range DNA content with a 6.1% SPF, although subsequent sampling of the resected tumor showed an aneuploid population with a DNA index of 1.8 and SPF of 2.1%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text