A chemo-enzymatic synthesis of optically active 1,1-diethoxyethyl(aminomethyl)phosphinates: useful chiral building blocks for phosphinyl dipeptide isosteres

Autor:	Terumitsu Haruki, Takehiro Yamagishi, Tsutomu Yokomatsu, Jun-ichirou Mori
Rok vydání:	2011
Předmět:	Dipeptide Chemistry Stereochemistry Organic Chemistry Imine Phosphinate Catalysis Kinetic resolution Inorganic Chemistry Acylation Turn (biochemistry) chemistry.chemical_compound Hydroxymethyl Physical and Theoretical Chemistry Chirality (chemistry)
Zdroj:	Tetrahedron: Asymmetry. 22:1358-1363
ISSN:	0957-4166
Popis:	The kinetic resolution of 1,1-diethoxyethyl(hydroxymethyl)phosphinate possessing chirality at the phosphorus atom was achieved via a lipase-catalyzed acylation. The product was transformed into the corresponding imine, which in turn is a useful starting material for the preparation of phosphinyl dipeptide isosteres.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::19704b914f61ddea4896405a8b03ef00 https://doi.org/10.1016/j.tetasy.2011.06.033 Zobrazit plný text záznamu Full Text from ScienceDirect