A chemo-enzymatic synthesis of optically active 1,1-diethoxyethyl(aminomethyl)phosphinates: useful chiral building blocks for phosphinyl dipeptide isosteres
Autor: | Terumitsu Haruki, Takehiro Yamagishi, Tsutomu Yokomatsu, Jun-ichirou Mori |
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Rok vydání: | 2011 |
Předmět: | |
Zdroj: | Tetrahedron: Asymmetry. 22:1358-1363 |
ISSN: | 0957-4166 |
Popis: | The kinetic resolution of 1,1-diethoxyethyl(hydroxymethyl)phosphinate possessing chirality at the phosphorus atom was achieved via a lipase-catalyzed acylation. The product was transformed into the corresponding imine, which in turn is a useful starting material for the preparation of phosphinyl dipeptide isosteres. |
Databáze: | OpenAIRE |
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