Anti-Angiogenic Properties of Vitreous
| Autor: | G.A. Lutty |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Thrombospondin
Pathology medicine.medical_specialty Fetus Retina genetic structures business.industry Cell Anatomy eye diseases Vascular endothelial growth factor Neovascularization chemistry.chemical_compound PEDF medicine.anatomical_structure chemistry medicine sense organs Endostatin medicine.symptom business |
| Popis: | Vitreous is vascularized in the fetus but is avascular through normal adult life. This gel changing from a pro-angiogenic to anti-angiogenic milieu accompanies the loss in vasculature. The avascularity of adult vitreous may be due to the myriad of anti-angiogenic proteins normally present that include transforming growth factor-β, pigment epithelial-derived factor, thrombospondin, and endostatin. In disease states such as diabetic and sickle cell retinopathies, preretinal neovascularization grows from retina into vitreous. These angiogenic events occur when there is a shift in balance between angiogenic factors such as vascular endothelial growth factor and anti-angiogenic factors and the vitreous returns to a pro-angiogenic environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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