Crx broadly modulates the pineal transcriptome

Autor:	David C. Klein, Morten Møller, Steven L. Coon, Thomas Litman, Diego Martin Bustos, Martin F. Rath, Louise Rovsing, Samuel Clokie, Kristian Rohde
Rok vydání:	2011
Předmět:	endocrine system Microarray analysis techniques Biology Biochemistry Molecular biology Pinealocyte Transcriptome Gene expression profiling Cellular and Molecular Neuroscience Pineal gland medicine.anatomical_structure Gene expression medicine Homeobox Hox gene
Zdroj:	Journal of Neurochemistry. 119:262-274
ISSN:	0022-3042
DOI:	10.1111/j.1471-4159.2011.07405.x
Popis:	Cone-rod homeobox (Crx) encodes Crx, a transcription factor expressed selectively in retinal photoreceptors and pinealocytes, the major cell type of the pineal gland. In this study, the influence of Crx on the mammalian pineal gland was studied by light and electron microscopy and by use of microarray and qRTPCR technology, thereby extending previous studies on selected genes (Furukawa et al. 1999). Deletion of Crx was not found to alter pineal morphology, but was found to broadly modulate the mouse pineal transcriptome, characterized by a>2-fold down-regulation of 543 genes and a>2-fold up-regulation of 745 genes (p
Databáze:	OpenAIRE
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