Efficacy of Ivermectin for Control of Microfilaremia Recurring after Treatment with Diethylcarbamazine

Autor:	Cheng Wf, Luo Lf, Piessens Wf, Zheng Hj, Chen Xr, Tao Zh, Gan Gb, Wang Sh, Cheng Sh, Ye Ym
Rok vydání:	1991
Předmět:	business.industry Helminthiasis medicine.disease medicine.disease_cause Diethylcarbamazine Serology Infectious Diseases Ivermectin Wuchereria bancrofti Immune system Antigen Virology parasitic diseases Immunology medicine Parasitology Anthelmintic business medicine.drug
Zdroj:	The American Journal of Tropical Medicine and Hygiene. 45:175-181
ISSN:	1476-1645 0002-9637
Popis:	We compared the effect of a single dose of ivermectin with that of a standard course of diethylcarbamazine (DEC) on several parameters of the host's antifilarial immune response in 60 patients with bancroftian filariasis enrolled in a double-blind drug trial. All participants had measurable serum levels of antifilarial antibodies and parasite antigens at the onset of the study. Drug-induced clearance of microfilaremia was associated with a temporary increase in HC 11 antigenemia and a decrease in serum levels of antibodies to soluble filarial antigens. Antigenemia progressively declined in patients who remained amicrofilaremic after treatment, but declined and then increased in persons with recurrent microfilaremia. Treatment triggered a sustained increase in serum levels of interleukin-1, tumor necrosis factor, and interleukin-6 in all patients studied. Although ivermectin and DEC are believed to exert their antiparasite activity via different mechanisms, the same pattern of serologic changes was observed in patients treated with either drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::196c50683805414436b53fcffcd12643 https://doi.org/10.4269/ajtmh.1991.45.175 Zobrazit plný text záznamu