Evidence for a cycloheximide-sensitive component in the biological clock of

Autor:	H.G. Schweiger, M.W. Karakashian
Rok vydání:	1976
Předmět:	biology Chloramphenicol Cell Cell Biology Cycloheximide Acetabularia biology.organism_classification chemistry.chemical_compound medicine.anatomical_structure Biochemistry chemistry Puromycin medicine Protein biosynthesis Circadian rhythm Eukaryotic Ribosome medicine.drug
Zdroj:	Experimental Cell Research. 98:303-312
ISSN:	0014-4827
DOI:	10.1016/0014-4827(76)90442-0
Popis:	An 8-h exposure to cycloheximide (0.1 μg/ml) delays the phase of the photosynthesis rhythm 6–14 h in individual Acetabularia cells monitored at 25 °C, providing the drug is present during the first half of a cell's circadian cycle. Puromycin pulses (50 μg/ml) are like cycloheximide in their effect on phase, but chloramphenicol (100 μg/ml) is ineffective. These results indicate that protein synthesis on 80S ribosomes provides a necessary component for the biochemical mechanism of circadian regulation in Acetabularia.
Databáze:	OpenAIRE
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