Silica gel catalyzed α-bromination of ketones using N-bromosuccinimide: An easy and rapid method

Autor:	Velpula Venkata Ramana Kumar, Nallagondu Chinna Gangi Reddy, Bodireddy Mohan Reddy, Siripragada Mahender Rao
Rok vydání:	2014
Předmět:	Solvent chemistry.chemical_compound Chlorinated solvents Chemistry Silica gel Halogenation Organic chemistry General Chemistry Methanol N-Bromosuccinimide Heterogeneous catalysis Catalysis
Zdroj:	Chinese Chemical Letters. 25:179-182
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2013.09.014
Popis:	An easy and rapid method for the α-bromination of ketones using N-bromosuccinimide (NBS) catalyzed by silica gel in methanol under reflux conditions was developed. The expected products were formed in excellent isolated yields within a short period of time (5–20 min). Major advantages of the present procedure include use of inexpensive and readily available catalyst, exclusion of pre- and post-chemical treatment of catalyst and use of methanol as solvent instead of ethers and chlorinated solvents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::195ffab6552ba72bb6ffc4f4556e111f https://doi.org/10.1016/j.cclet.2013.09.014 Zobrazit plný text záznamu Full Text from ScienceDirect