Production of Anti-W24 Xenoantisera in Rabbits1

Autor:	Soldano Ferrone, Ralph A. Reisfeld, Ronald Billing, Michele A. Pellegrino, PaulI. Terasaki
Rok vydání:	2008
Předmět:	DNA synthesis T cell Immunology Stimulation General Medicine Biology Mixed lymphocyte reaction Biochemistry Molecular biology medicine.anatomical_structure Antigen Genetics biology.protein medicine Immunology and Allergy Cytotoxic T cell Platelet Antibody
Zdroj:	Tissue Antigens. 5:41-47
ISSN:	1399-0039 0001-2815
DOI:	10.1111/j.1399-0039.1975.tb00525.x
Popis:	One out of four rabbits injected with partially purified soluble HL–A antigen from serum produced cytotoxic antibodies to human lymphocytes. These antibodies appear to be directed tc the specificity W24 as determined by correlation studies with HL–A alloantisera and by absorption-inhibition experiments with human platelets and with serum soluble HL–A antigens. In the sera from the other three immunized rabbits, no antibodies to human lymphoid cells could be detected by the cytotoxic test, blocking of T cell rosette formation, stimulation of DNA synthesis and inhibition of mixed lymphocyte reaction.
Databáze:	OpenAIRE
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