Synthetic of α-Methylhistidine by Catalytic Phase-Transfer Alkylations

Autor:	David B. Rusterholz, Martin J. O'Donnell
Rok vydání:	1989
Předmět:	chemistry.chemical_compound Hydrolysis Schiff base chemistry Yield (chemistry) Organic Chemistry Electrophile Organic chemistry Alkylation Combinatorial chemistry Histidine Derivative (chemistry) Catalysis
Zdroj:	Synthetic Communications. 19:1157-1165
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397918908054518
Popis:	α-Methylhistidine was prepared by two complementary routes using a catalytic phase-transfer alkylation procedure. Construction of the product was achieved either by alkylation of an alanine Schiff base ester with an imidazole-containing electrophile or by methylation of a protected histidine derivative. Hydrolysis of the protecting groups afforded α-MeHis·2HCl in 27–41% overall yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1951177eac65d410a0a10602ef6e3863 https://doi.org/10.1080/00397918908054518 Zobrazit plný text záznamu