| Autor: |
Samuel Katsuyuki Shinjo, Mariana Teichner de Moraes, Fernando Henrique Carlos de Souza, Thiago Bitar Moraes Barros |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Arthritis Care & Research. 65:793-799 |
| ISSN: |
2151-464X |
| DOI: |
10.1002/acr.21879 |
| Popis: |
Objective To evaluate the frequency of metabolic syndrome in dermatomyositis (DM) patients and to analyze the possible association of metabolic syndrome with traditional cardiovascular disease (CVD) risk factors and DM-related clinical and laboratory features. Methods The present cross-sectional single-center study included 84 DM patients and 105 healthy controls. Metabolic syndrome was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III. Results The median age was similar in both the DM and control groups (41.5 and 42.0 years, respectively; P = 0.378), with a comparable predominance of women (P = 0.904) and white race (P = 0.623). The DM patients had a higher prevalence of metabolic syndrome (41.7% versus 7.0%; P 0.05). Further analysis of the DM patients with (n = 35) and without (n = 49) metabolic syndrome revealed that the patients with this complication were older (mean ± SD age 50.0 ± 14.5 years versus 40.9 ± 14.6 years; P = 0.006) and had a similar disease duration (P = 0.925) and higher prevalence of systemic arterial hypertension prior to the onset of disease symptoms (54.3% versus 10.2%; P < 0.001). In a multivariate analysis, only hypertension diagnosed prior to the disease was associated with metabolic syndrome (odds ratio 10.47 [95% confidence interval 2.62–44.81]). Conclusion Metabolic syndrome is highly prevalent in DM, and prior hypertension seems to be a major determinant of its development, while disease- and therapy-related factors do not appear to play a relevant role. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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