Neutrophil depletion does not prevent indomethacin-induced ulceration of the rat gastric antrum
| Autor: | M. A. Trevethick, P. Strong, S. Sanjar, A. K. Bahl, N. M. Clayton |
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| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
Pathology medicine.medical_specialty Allergy business.industry digestive oral and skin physiology Immunology Pharmacology toxicology Toxicology medicine.disease Blood neutrophil digestive system digestive system diseases Surgery Pathogenesis Medicine Pharmacology (medical) Gastric antrum business Infiltration (medical) Antrum |
| Zdroj: | Agents and Actions. 41:C226-C227 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01987647 |
| Popis: | Indomethacin-induced ulceration of the rat gastric antrum is paralleled by an increase in blood neutrophil numbers and of neutrophil infiltration into the antrum. Thus, in this study, neutrophil depletion has been employed to study the potential role of neutrophils in the pathogenesis of indomethacin-induced ulceration of the rat gastric antrum. Pretreatment with an anti-neutrophil serum (ANS) induced a near complete neutropaenia and inhibition of neutrophil infiltration into the gastric antrum (as assessed by antral LTB4 release). In contrast, ANS pretreatment did not alter the area of indomethacin-induced mucosal damage detected microscopically. |
| Databáze: | OpenAIRE |
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