Bone Mineral Mass and Calcium and Phosphate Metabolism in Young Men: Relationships with Vitamin D Receptor Allelic Polymorphisms1
| Autor: | D. Slosman, S. Ferrari, Jean-Philippe Bonjour, D. Manen, René Rizzoli |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Bone mineral
Calcium metabolism Peak bone mass medicine.medical_specialty biology Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry chemistry.chemical_element Calcium Biochemistry Calcitriol receptor FokI Endocrinology chemistry Polymorphism (computer science) Internal medicine medicine biology.protein Vitamin D and neurology |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 84:2043-2048 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.84.6.5790 |
| Popis: | The genetic bases of peak bone mass determinants are still poorly understood, particularly in males. We investigated the relationship between vitamin D receptor (VDR) 3'- and 5'-gene polymorphisms (as determined by the restriction enzymes BsmI and FokI) and bone mineral mass, and calcium and inorganic phosphate (Pi) metabolism in an homogeneous cohort of young healthy men. In 104 healthy subjects, aged 24.3 +/- 3.1 yr (mean +/- SD; range, 20.7-38.7), standardized bone mineral density (BMD; z-scores) at the levels of lumbar spine and femoral trochanter, i.e. bone mineral content adjusted for age, body size, and bone area, significantly differed between VDR 3'-end alleles (BsmI), whereas crude areal BMD or bone mineral content did not. Among BsmI homozygotes BB, BMD (z-scores) were significantly lower only in subjects also carrying the f allele at the VDR-5' polymorphic site (FokI). Serum PTH levels were significantly higher in the BB genotype at baseline and remained so under either a low or a high calcium-phosphorus diet. Moreover, on the low calcium-phosphorus diet, BB subjects had significantly decreased tubular Pi reabsorptive capacity and plasma Pi levels. Our results underline the importance of identifying multiple single base mutation polymorphisms within candidate genes of bone mineral mass and suggest a role for environmental/dietary factor interactions with VDR gene polymorphisms in peak bone mineral mass in men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|