Spongiform Leukoencephalopathy Induced in Mice by Oral Benzidine Administration
| Autor: | Charles H. Frith, G. Coleman, D. M. Crowder, N. Littlefield, K. T. Morgan |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Superior thalamic radiation
Pathology medicine.medical_specialty Internal capsule 040301 veterinary sciences Benzidine dihydrochloride 04 agricultural and veterinary sciences Cell Biology Vacuole Toxicology medicine.disease 030226 pharmacology & pharmacy Benzidine Pathology and Forensic Medicine 0403 veterinary science Leukoencephalopathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry medicine Molecular Biology |
| Zdroj: | Toxicologic Pathology. 9:4-8 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/019262338100900102 |
| Popis: | Small foci of spongy change, often bilaterally symmetric, were observed in the brains of mice exposed to benzidine dihydrochloride. These vacuoles were most frequent in the superior thalamic radiation of the internal capsule. They possibly represent swollen glial cells and intramyelinic vacuoles. No consistent relationship was observed between the presence of vacuoles in the brain and hepatic lesions in these mice, and this change may be attributable to benzidine treatment unrelated to toxic effects of the liver. |
| Databáze: | OpenAIRE |
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