Is there a role for multi-gene screening panels in patients who previously underwent noninformative genetic testing?
Autor: | Sarah H. Kim, Rebecca Yee Bassett, Melissa K. Frey, Stephanie V. Blank, Jessica Martineau |
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Rok vydání: | 2015 |
Předmět: | |
Zdroj: | Journal of Clinical Oncology. 33:1536-1536 |
ISSN: | 1527-7755 0732-183X |
DOI: | 10.1200/jco.2015.33.15_suppl.1536 |
Popis: | 1536 Background: The availability of next-generation sequencing coupled with the recent discovery of multiple cancer-related genes has caused a shift away from single gene testing towards multi-gene panel testing for familial cancer syndromes. However, the utility of multi-gene panels in individuals who previously underwent noninformative genetic screening has yet to be evaluated. We aim to evaluate the use of rescreening and results of multi-gene panels in this rescreened population. Methods: We reviewed all patients who had previously undergone genetic testing for familial cancer syndromes and then underwent multi-gene panel testing at a single institution between 9/2013-11/2014. Results: One hundred and twenty-four patients with prior non multi-gene panel testing underwent multi-gene panels. One hundred patients (81%) had a history of cancer and 115 patients (93%) had at least one family member with cancer. On primary testing, no deleterious mutations were identified and 11 variants of uncertain signif... |
Databáze: | OpenAIRE |
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