Synthesis, antifungal and nematocidal activities of thioureines with an aminoester sequence

Autor:	Philippe Gayral, J. P. Seguela, Christian Bories, H Amarouch, Linas, R Caujolle, Marc Payard, Philippe M. Loiseau
Rok vydání:	1995
Předmět:	Pharmacology Aspergillus biology Chemistry Stereochemistry Organic Chemistry General Medicine Fungi imperfecti biology.organism_classification Chemical synthesis In vitro Drug Discovery Nitro medicine Potency Anthelmintic Aliphatic compound medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 30:801-807
ISSN:	0223-5234
Popis:	Twenty-three arylthioureines bearing β-alanine or γ-aminobutyric alkyl ester chains were synthesized for in vitro screening toward 44 strains of fungi and 2 genera of nematodes. The nitro derivatives were the most potent compounds against Aspergillus and Candida strains. Ester chains increase activity against the filarial worm Molinema dessetae. Twelve compounds have EC 50 < 40 μg/ml. However, the anthelmintic potency is weak compared with tetramisole
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::191e968f0e7f16faa73c7e0b24718c63 https://doi.org/10.1016/0223-5234(96)88299-7 Zobrazit plný text záznamu Full Text from ScienceDirect