Endothelial dysfunction, ambulatory pulse pressure and albuminuria are associated in Type 2 diabetic subjects
| Autor: | C. E. Mogensen, Per Bendix Jeppesen, Niels Holmark Andersen, Søren Tang Knudsen, Jørgen Ingerslev, Christian Alcaraz Frederiksen, Toke Bek, Per Løgstrup Poulsen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure Endothelium business.industry Endocrinology Diabetes and Metabolism Type 2 diabetes medicine.disease Endothelial activation Endocrinology Blood pressure medicine.anatomical_structure Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria Endothelial dysfunction medicine.symptom business |
| Zdroj: | Diabetic Medicine. 24:911-915 |
| ISSN: | 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2007.02197.x |
| Popis: | Aim Elevated pulse pressure (PP) is associated with microvascular complications in Type 2 diabetic patients. In non-diabetic subjects, elevated PP has been associated with endothelial dysfunction. The relation between endothelial dysfunction and PP in diabetic subjects has not previously been examined. We examined the relation between PP, markers of endothelial activation and albuminuria in Type 2 diabetic patients. Methods In 46 Type 2 diabetic patients and 19 non-diabetic subjects, we performed 24-h ambulatory blood pressure (AMBP) monitoring. Urinary albumin excretion rate was measured as three urinary albumin/creatinine ratios. Von Willebrand factor (vWF), fibrinogen, E-selectin and soluble intercellular adhesion molecule 1 (ICAM-1) were measured in plasma. Results Thirty-four patients had normoalbuminuria (group N) and 12 had micro- or macroalbuminuria (group A). PP levels increased in a stepwise manner from the control group (group C) to group N and group A; night PP 43 ± 5, 48 ± 10 and 59 ± 12 mmHg (groups C, N and A, respectively, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text