Assessment of In Vivo Kidney Cell Death: Glomerular Injury
| Autor: | Wulf Tonnus, Christian Hugo, Moath Al-Mekhlafi, Florian Gembardt, Andreas Linkermann |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty urogenital system business.industry 030232 urology & nephrology 030204 cardiovascular system & hematology urologic and male genital diseases Secondary Focal Segmental Glomerulosclerosis medicine.disease female genital diseases and pregnancy complications Podocyte Endothelial stem cell 03 medical and health sciences Nephritic syndrome 0302 clinical medicine Focal segmental glomerulosclerosis medicine.anatomical_structure Mesangiolysis medicine Mesangial proliferative glomerulonephritis business Nephrotic syndrome |
| Zdroj: | Programmed Necrosis ISBN: 9781493987535 |
| DOI: | 10.1007/978-1-4939-8754-2_14 |
| Popis: | The glomerulus functions as the filtration unit of the kidney. The mesangial, endothelial, and podocyte cells of the glomerulus exhibit the three clinically most important cell types, which are involved in diverse pathologic processes. Cell death has hardly been investigated in these cells but may be of critical importance to the pathogenesis of nephrotic syndrome, nephritic syndrome, focal segmental glomerulosclerosis (FSGS), mesangial proliferation, and thrombonic microangiopathy (which involves dysfunction and death of glomerular endothelial cells). The complexity of the glomerulus is frequently affected in autoimmune disorders, which may elicit cell death in mesangial cells and glomerular endothelia. Artificial antisera are used to induce anti-mesangial cell serum-induced mesangiolysis and selective endothelial cell injury, respectively. Genetic variations result in loss of function of podocytes and nephrotic syndrome, which may encompass similar cell death mechanisms as the ones that are observed in the model of secondary focal segmental glomerulosclerosis (FSGS). The following protocols describe our current arsenal to target glomerular cells in vivo. |
| Databáze: | OpenAIRE |
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