Phenytoin Attenuates Seizure Severity and Hippocampal Derangement than Levetiracetam or Phenytoin-Levetiracetam Adjunctive Treatment in Electrically-Convulsed Mice
| Autor: | Olayemi Olutobi Oladokun, Opeyemi Samson Osuntokun, Damilare Adedayo Adekomi, Gbola Olayiwola, Kabiru Isola Adedokun |
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| Rok vydání: | 2021 |
| Předmět: |
Phenytoin
History Polymers and Plastics Clonic Convulsion business.industry medicine.medical_treatment Industrial and Manufacturing Engineering Anticonvulsant Anesthesia Statistical significance Convulsion Adjunctive treatment Medicine Righting reflex Levetiracetam Business and International Management medicine.symptom business medicine.drug |
| Zdroj: | SSRN Electronic Journal. |
| ISSN: | 1556-5068 |
| DOI: | 10.2139/ssrn.3959608 |
| Popis: | This study evaluated the anticonvulsant and neuroprotective efficacy of individual or adjuvant treatment of two different antiepileptic-drugs (AEDs) phenytoin (PHT) and levetiracetam (LEV) against maximal electric shock in mice model. Twenty-five male Albino mice, randomized into five groups (n=5) received treatment as follows: groups 1 and 2 received intraperitoneal (i.p) administration of normal saline (0.1 ml), while groups 3-5 received a therapeutic dose of PHT (50 mg/kg BW) or LEV (50 mg/kg/day BW), or combination of PHT (25 mg/kg) and LEV (25 mg/kg) at sub-therapeutic doses. Thirty minutes later, the mice in groups 2-5 were challenged with maximal electroshock, while various indices of convulsion were determined, while the histomorphological profile of the hippocampus investigated. Data were analyzed using descriptive and inferential statistics with the help of graph pad prism software. The results were presented as mean ± SEM in the graph or table. The level of significance was taken at p |
| Databáze: | OpenAIRE |
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