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Aim: It is highly intricate to categorize a solitary or prevailing factor for pathophysiology of varicocele. Herein, the basis of free radicals in the pathogenesis of varicocele was assessed. Study Design: Experimental using animal models. Place and Duration of Study: Department of Anatomy, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria, between April, 2012 and August, 2012. Methodology: Five (5) groups of rats were used, Group A animals served as the control, while Groups B, C, D and E animals were varicocelized. Groups C, E and E in addition, had intramuscular treatment of 25 mg/kg, 50 mg/kg and 75mg/kg body weight of α-tocopherol respectively. The models were sacrificed on 65th day and Testicular weights and volumes, sperm parameters, histology, morphometry, enzymatic and non enzymatic antioxidants were vastly estimated. Result: There was a significant (p |
