A new coumarin glucoside ester from seeds oil leavings of Xanthoceras sorbifolia
| Autor: | Jia-chuan Liu, Tong Zhang, Feng Qiu, Li-li Yu, Mei-yu Wang, Hong-jin Zhu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Chromatography biology Silica gel Xanthoceras biology.organism_classification Coumarin 030226 pharmacology & pharmacy 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Column chromatography Complementary and alternative medicine chemistry Glucoside Sephadex Pharmacology (medical) Fraxetin Cytotoxicity |
| Zdroj: | Chinese Herbal Medicines. 11:113-115 |
| ISSN: | 1674-6384 |
| DOI: | 10.1016/j.chmed.2018.09.003 |
| Popis: | Objective To study the coumarin from the seeds oil leavings of Xanthoceras sorbifolia. Methods The chemical constituents were isolated and purified by combination of silica gel, macroporous resin, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by spectral and chemical methods. The cytotoxicity of the new compound against 10 selected human cancer cell lines was assayed. Results Five comarins were isolated and identified as fraxetin-7-O-β- d -[6'-(3''‑hydroxyl‑3''- methylglutaryl)] glucopyranoside (1), fraxoside (2), fraxetin (3), scopoline (4), and esculetin (5), respectively. Conclusion Compound 1 is a new compound. Unfortunately, this compound exhibited no cytotoxicity with tested cell lines. |
| Databáze: | OpenAIRE |
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