Can compartment models account for nonmonotonicity in pharmacokinetics?
| Autor: | Jean-François Boisvieux, Y. Plusquellec, J.L. Steimer |
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| Rok vydání: | 1982 |
| Předmět: |
Statistics and Probability
State variable General Immunology and Microbiology Statement (logic) Applied Mathematics Mathematical analysis Zero (complex analysis) Monotonic function General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Pharmacokinetics Modeling and Simulation Time course General Agricultural and Biological Sciences Compartment (pharmacokinetics) Mathematics |
| Zdroj: | Mathematical Biosciences. 58:19-25 |
| ISSN: | 0025-5564 |
| Popis: | The purpose of this paper is to show that for most of the compartment models used in pharmacokinetics, when initial conditions are zero except in one compartment, the time course of the corresponding state variable is monotonic decreasing. This statement is in contradiction with two related papers of Vaidhyanathan [1, 2], but is shown to be a consequence of theorems derived by Hearon [3]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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