Mechanochemical self-organization determines search pattern in migratory cells

Autor: Isabel Rathmann, David Grill, Volker Gerke, Christiane Rasch, Britta Trappmann, Lucas Lamparter, Tanumoy Saha, Maja Matis, Jürgen Klingauf, L. Golbach, Ulrike Keller, Milos Galic, Isabell Begemann
Rok vydání: 2019
Předmět:
Zdroj: Nature Physics. 15:848-857
ISSN: 1745-2481
1745-2473
DOI: 10.1038/s41567-019-0505-9
Popis: To reach their destination, migrating cells rely on polarized signal inputs to align the direction of their motion. However, navigational guidance cues are not always present, which establishes the need for exploratory search mechanisms in cells seeking signal inputs. Here, we investigate how non-Brownian search patterns emerge in adherent vertebrate cells. Combining experimental and theoretical analysis, we demonstrate that nanoscale plasma membrane deformations nucleate a mechanochemical feedback loop that mediates longevity of the cell’s leading edge, a necessary requirement for directed cell migration. We further observe stochastic transitions between phases of random and persistent cell motion, whereby the mechanochemical circuit augments cell persistence and search area. Collectively, these findings are consistent with a self-organizing system for a superdiffusive pattern of motion that is spontaneously employed by migratory cells in the absence of external signal inputs. A study of how migrating cells optimize their search efficiency in the absence of directional cues reveals a self-organizing system that mediates superdiffusive motion—and sheds light on how cells navigate noisy environments.
Databáze: OpenAIRE
Externí odkaz: