ChemInform Abstract: Synthesis of 3-Substituted 4-Sulfanyl-8-methoxyisoquinolin-1(2H)-ones by the Reaction of Ethyl 2-[Lithio(sulfanyl)methyl]-6-methoxybenzoates with Aliphatic and Aromatic Nitriles

Autor:	Hiroo Hashimoto, Kazuhiro Nakagawa, Kazuhiro Kobayashi
Rok vydání:	2012
Předmět:	chemistry.chemical_compound Methoxybenzoates Deprotonation chemistry Sulfanyl Sodium Organic chemistry chemistry.chemical_element General Medicine Lithium diisopropylamide
Zdroj:	ChemInform. 43
ISSN:	0931-7597
DOI:	10.1002/chin.201233168
Popis:	Intermediates (III), obtained by reaction of ethyl halomethylmethoxybenzoates (I) with sodium thiolates, are deprotonated upon treatment with lithium diisopropylamide to generate the corresponding benzyl anions, which react smoothly with a variety of nitriles to afford satisfactory to very good yields of the desired isoquinolinones (V) and (VII).
Databáze:	OpenAIRE
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