Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease
Autor: | Michelle A Babicz, Erin E. Morgan, Antônio Lúcio Teixeira, Gabriela D. Colpo, Lokesh R Shahani, Steven Paul Woods |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Brain-derived neurotrophic factor business.industry Context (language use) medicine.disease Profile of mood states Neuropsychiatry 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Mood Neurology Mood disorders Virology Medicine Major depressive disorder Neurology (clinical) business 030217 neurology & neurosurgery Depression (differential diagnoses) Clinical psychology |
Zdroj: | Journal of NeuroVirology. 27:70-79 |
ISSN: | 1538-2443 1355-0284 |
DOI: | 10.1007/s13365-020-00916-2 |
Popis: | Symptoms of depression are common among persons with HIV (PWH) and can have a significant impact on socioeconomic and personal well-being, but little is known about their neurobiological substrates in the context of HIV disease. This study examined the possible role of brain-derived neurotrophic factor (BDNF) in symptoms of depression and other aspects of mood in 109 PWH and 43 seronegative participants aged 50 and older. Participants completed the Profile of Mood States (POMS) which measured six dimensions of mood and was normatively adjusted for sex. A model controlling for medical comorbidities and substance use diagnoses among PWH showed a significant interaction between BDNF and POMS subscales. Planned post hoc analyses revealed that lower BDNF was only associated with higher scores on Depression-Dejection and Confusion-Bewilderment POMS subscales among PWH and at small-to-medium effect sizes. Lower levels of BDNF were associated with AIDS diagnoses and CD4 count, but not with viremia or duration of infection. BDNF levels did not differ between the PWH and HIV − samples, and there were no significant correlations between BDNF and any POMS variable in the HIV − group. Findings implicate BDNF in the neuropathophysiology of specific depressive symptoms in the context of HIV disease. Future studies may examine whether BDNF levels change over time, are sensitive to other aspects of mood disorders in HIV, and are associated with markers of HIV-associated neural injury. |
Databáze: | OpenAIRE |
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