Thiol addition to aryl propargyl alcohols under mild conditions: an accelerating neighboring group effect

Autor:	Jennifer A. Cowen, Marjorie S. Waters, David Askin, Peter E. Maligres, J. Christopher McWilliams
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Aryl Organic Chemistry Triple bond Biochemistry Medicinal chemistry chemistry.chemical_compound Hydrolysis chemistry Drug Discovery Functional group Propargyl Thiol Group effect
Zdroj:	Tetrahedron Letters. 41:141-144
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)02040-7
Popis:	Aryl alkynols provide a convenient entry into α-hydroxyketones via thiol addition followed by hydrolysis. Thiols have been added to several non-activated alkynes under mild, basic conditions. A coordinating functional group in close proximity to the triple bond facilitates this reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::18adf4d74ef02ec1d4a93d99dc774d72 https://doi.org/10.1016/s0040-4039(99)02040-7 Zobrazit plný text záznamu Full Text from ScienceDirect