Streptococcus pneumoniae serotype 19A: worldwide epidemiology
| Autor: | Raul E Isturiz, Adriano Arguedas, Heather L Sings, Ralf-Rene Reinert, Betsy Hilton, Luis Jodar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Serotype medicine.medical_specialty 030106 microbiology Immunology Prevalence medicine.disease_cause complex mixtures Pneumococcal conjugate vaccine 03 medical and health sciences 0302 clinical medicine stomatognathic system Drug Discovery Streptococcus pneumoniae Epidemiology medicine 030212 general & internal medicine Pharmacology business.industry Virology Vaccination Carriage Immunization Molecular Medicine business medicine.drug |
| Zdroj: | Expert Review of Vaccines. 16:1007-1027 |
| ISSN: | 1744-8395 1476-0584 |
| Popis: | Introduction: Streptococcus pneumoniae causes mucosal and invasive diseases with high morbidity and mortality. Introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) into routine infant immunization programs worldwide resulted in serotype 19A becoming a leading cause of the remaining pneumococcal disease burden in vaccinated and nonvaccinated individuals. This article reviews the impact of the latest generation PCVs (10-valent PCV, PCV10, and 13-valent PCV, PCV13) on serotype 19A.Areas covered: This article covers immune responses elicited by PCV7, PCV10 and PCV13 against serotype 19A and their impact on nasopharyngeal (NP) carriage and disease in vaccinated and unvaccinated populations using data from surveillance systems, randomized controlled trials, and observational studies.Expert commentary: As expected from a PCV containing serotype 19A, PCV13 elicits significantly higher functional immune responses against serotype 19A than PCV7 and PCV10. Higher responses are likely to be link... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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