Synthesis of hydrazino-peptide nucleic acid monomers and dimers as new PNA backbone building blocks

Autor:	Paolangelo Cerea, Sergio Dall'Angelo, Stefano Maiorana, Clelia Giannini, Emanuela Licandro, Rosangela Marchelli
Rok vydání:	2007
Předmět:	chemistry.chemical_compound Monomer chemistry Nitrogen atom Peptide nucleic acid Stereochemistry Organic Chemistry Drug Discovery Hydrazine Moiety Biochemistry
Zdroj:	Tetrahedron. 63:4108-4119
ISSN:	0040-4020
Popis:	We describe the synthesis of new hydrazinoPNA (hydPNA) monomers and new hydPNA-containing dimers. For the hydPNA monomers, the primary terminal amino group of the aminoethylglycine unit of classical aegPNA is replaced by a hydrazine moiety. An appropriate choice of two orthogonal protecting groups on the two hydrazine nitrogen atoms makes it possible to drive their coupling with other monomers selectively on one or the other nitrogen atom, thus obtaining two different types of PNA dimers. These dimers represent new building blocks that can be used to generate novel PNA oligomers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::18a7922f92627c767171f5e62b07c842 https://doi.org/10.1016/j.tet.2007.02.102 Zobrazit plný text záznamu Full Text from ScienceDirect