Mitomycin C bei der Behandlung von Bindehautmelanomen und primär erworbenen Melanosen

Autor:	Peter K. Lommatzsch, Cornelia Werschnik
Rok vydání:	1998
Předmět:	medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Eye disease Mitomycin C Cryotherapy Pigmentations Eye drop medicine.disease Dermatology Melanosis Surgery Ophthalmology medicine business Conjunctival Melanoma
Zdroj:	Klinische Monatsblätter für Augenheilkunde. 212:465-468
ISSN:	1439-3999 0023-2165
DOI:	10.1055/s-2008-1034931
Popis:	BACKGROUND Since 1995 we have used Mitomycin C additionally in the treatment of conjunctival melanoma and primary acquired melanosis. METHODS We report on the therapy results of 14 patients suffering from pigmented conjunctival lesions (malignant melanoma 9 and primary acquired melanosis 5). After local excision, cryotherapy or irradiation all patients received one eye drop Mitomycin C (0.02%) four times daily for four to six weeks. RESULTS We observed regression of the pigmentations in 11 cases after median follow up of 13.1 months. In one patient there was no change. Two cases showed progression with tumefaction. There were no adverse reactions except conjunctival hyperemia during therapy. CONCLUSIONS Topical administration of Mitomycin C may be useful in the treatment of pigmented conjunctival lesions. Longer follow-up periods are necessary.
Databáze:	OpenAIRE
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