The biosynthesis of protoberberine and related isoquinoline alkaloids

Autor:	David B. MacLean, Herbert L. Holland, Thomas M. Capps, Peter W. Jeffs
Rok vydání:	1979
Předmět:	biology Stereochemistry Organic Chemistry General Chemistry Corydaline biology.organism_classification Catalysis Hydrastine chemistry.chemical_compound Berberine chemistry Biosynthesis medicine Protopine Organic chemistry Isoquinoline Corydalis solida medicine.drug
Zdroj:	Canadian Journal of Chemistry. 57:1588-1597
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v79-258
Popis:	The biosynthesis of berberine and hydrastine (in Hydrastis canadensis), corydaline and protopine (in Corydalis solida), and ochotensimine and protopine (in C. ochotensis), has been investigated by the administration of [3-14C]-3′,4′-dihydroxyphenylalanine ([3-14C]DOPA). In all cases, incorporation of label was predominantly into the isoquinoline portion of the alkaloid. The role of DOPA in the early stages of isoquinoline alkaloid biosynthesis in these plants is discussed in the light of this and other relevant data. In addition, the later stages of corydaline biosynthesis have been studied by the administration of [9-methoxy-14C]palmatine and -tetrahydropalmatine to C. solida, and the origin of the exocyclic carbons of ochotensimine further verified by feeding [methyl-14C,3H]methionine to C. ochotensis.
Databáze:	OpenAIRE
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