| Autor: |
Jianhe Liang, Longxiang Lin, Yanmei Zhang, Yun Yang, Pinliang Jiang, Duan Hongping, Xiang Dong, Ran Song, Qiaoling Huang, Changjian Lin |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Electrochimica Acta. 174:1149-1159 |
| ISSN: |
0013-4686 |
| DOI: |
10.1016/j.electacta.2015.06.100 |
| Popis: |
Biomimetic surface design of medical implants is vitally crucial to improve cellular responses and the integration of tissue onto materials. In this study, a novel hierarchical cell-sized microhole array combined with a nano-network structure was fabricated on a medical titanium surface to mimic multi-level bone structure. A three-step procedure was developed as follows: 1) electrochemical self-organization of etching on titanium substrate to create highly ordered cell-sized microhole arrays, 2) suitable dual acid etching to increase the roughness of the microholes, and then 3) electrochemical anodization in a NaOH electrolyte to construct a nano-network porous titania layer on the above micro-roughened surface. The bio-inspired micro/nano-textured structure presented the enhanced wettability and superhydrophilicity. The ability of in vitro biomineralization and corrosion resistance of the bio-inspired micro/nano-textured structure were enhanced after annealing treatment. More importantly, the bio-inspired micro/nano-textured structure on the titanium surface possessed a favourable interfacial environment to enhance attachment and proliferation of human osteoblast-like MG63 cells. All of the results demonstrated that such a bio-inspired surface of micro/nano-textured porous TiO 2 is a most promising candidate for the next generation of titanium implants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect