Popis: |
Oxygen free radicals have been implicated as a major factor of organ tissue damage in an array of diseases (heart: McCord 1988, intestine: Kaminski and Proctor 1990, endothelium: Matsubara and Ziff 1986, muscle: Freischlag and Hanna 1991, lung: Till et al. 1991, liver: Reinke et al. 1991). In the nervous system, oxygen free radicals have been incriminated as mediators of neurodegeneration (Adams and Odunze 1991), brain trauma (Ikeda et al. 1989), ischemia-reperfusion (Traystman et al. 1991) and inflammation (Fantone and Ward 1982, McCord 1987). |