THE EFFECTS OF P-ALAXIN ON FERTILITY AND HEMATOLOGICAL PARAMETERS IN MALE ADULT WISTAR RATS

Autor:	Raheem Akinwunmi Akindele, Ifabunmi Oduyemi Osonuga, Gbolahan O Idowu, Thomas Kehinde Adenowo
Rok vydání:	2020
Předmět:	Anemia business.industry medicine.medical_treatment General Engineering Physiology Dihydroartemisinin Semen medicine.disease Sperm Oral administration medicine business Saline Sperm motility Testosterone
Zdroj:	African Journal of Science and Nature. 10:97
ISSN:	2705-2761 2536-6904
DOI:	10.46881/ajsn.v10i0.182
Popis:	P-Alaxin, is an anti-malarial drug that is highly effective in treating malaria all forms of malarial infection including multi drug resistance malaria in areas of high resistance especially in Africa. It is composed of dihydroartemisinin and piperaquine phosphate. This study investigates the effects of therapeutic dose of P-alaxin on fertility and hematological indices in rats. Fifteen male adult Wistar rats weighing between 150 and 220g were divided into three consisting of 5 rats per group. Normal saline was administered to the control group while the test and recovery groups were given 15.4mg/kg body weight of P-Alaxin orally for three days. The recovery group was allowed to recover for three days from the drug's effect. The animals were anaesthetized using diethyl ether. Blood samples were collected through cardiac puncture. Oral administration of P-alaxin (15.4mg/kg body weight) for three days reduced (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::187673a0dc3a85dfe461ac7cf251d501 https://doi.org/10.46881/ajsn.v10i0.182 Zobrazit plný text záznamu