Increasing global access to the high-volume HIV drug nevirapine through process intensification
| Autor: | D. Tyler McQuade, Katherine Belecki, Caleb J. Kong, B. Frank Gupton, Julie B. Manley, Saeed Ahmad, Daniel Rivalti, Rudy Krack, Jesús Alcázar, Eric C. Yu, Jenson Verghese |
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| Rok vydání: | 2017 |
| Předmět: |
Active ingredient
Drug Nevirapine 010405 organic chemistry Process (engineering) media_common.quotation_subject Human immunodeficiency virus (HIV) Developing country Pharmacology 010402 general chemistry medicine.disease_cause 01 natural sciences Pollution 0104 chemical sciences Drug access Risk analysis (engineering) medicine Global health Environmental Chemistry Business medicine.drug media_common |
| Zdroj: | Green Chemistry. 19:2986-2991 |
| ISSN: | 1463-9270 1463-9262 |
| Popis: | Access to affordable medications continues to be one of the most pressing issues for the treatment of disease in developing countries. For many drugs, synthesis of the active pharmaceutical ingredient (API) represents the most financially important and technically demanding element of pharmaceutical operations. Furthermore, the environmental impact of API processing has been well documented and is an area of continuing interest in green chemical operations. To improve drug access and affordability, we have developed a series of core principles that can be applied to a specific API, yielding dramatic improvements in chemical efficiency. We applied these principles to nevirapine, the first non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV. The resulting ultra-efficient (91% isolated yield) and highly-consolidated (4 unit operations) route has been successfully developed and implemented through partnerships with philanthropic entities, increasing access to this essential medication. We anticipate an even broader global health impact when applying this model to other active ingredients. |
| Databáze: | OpenAIRE |
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