Comparison of the photothermal effects of 808nm gold nanorod and indocyanine green solutions using an 805nm diode laser
| Autor: | Connor L. West, Wei R. Chen, Feifan Zhou, Aamr M. Hasanjee, Austin Doughty, Cody F. Bahavar, Kegan Silk |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
genetic structures business.industry Photothermal effect Analytical chemistry 02 engineering and technology Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology Laser 01 natural sciences 0104 chemical sciences Semiconductor laser theory law.invention body regions chemistry.chemical_compound chemistry law Optoelectronics Nanorod Irradiation 0210 nano-technology business Indocyanine green Diode |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| Popis: | Non-invasive laser immunotherapy (NLIT) is a treatment method for metastatic cancer which combines noninvasive laser irradiation with immunologically modified nanostructures to ablate a primary tumor and induce a systemic anti-tumor response. To further expand the development of NLIT, two different photosensitizing agents were compared: gold nanorods (GNR) with an optical absorption peak of 808 nm and indocyanine green (ICG) with an optical absorption peak of ~800 nm. Various concentrations of GNR and ICG solutions were irradiated at different power densities using an 805 nm diode laser, and the temperature of the solutions was monitored during irradiation using a thermal camera. For comparison, dye balls made up of a 1:1 volume ratio of gel solution to GNR or ICG solution were placed in phantom gels and were then irradiated using the 805 nm diode laser to imitate the effect of laser irradiation on in vivo tumors. Non-invasive laser irradiation of GNR solution for 2 minutes resulted in a maximum increase in temperature by 31.8 °C. Additionally, similar irradiation of GNR solution dye ball within phantom gel for 10 minutes resulted in a maximum temperature increase of 8.2 °C. Comparatively, non-invasive laser irradiation of ICG solution for 2 minutes resulted in a maximum increase in temperature by 28.0 °C. Similar irradiation of ICG solution dye ball within phantom gel for 10 minutes yielded a maximum temperature increase of only 3.4 °C. Qualitatively, these studies showed that GNR solutions are more effective photosensitizing agents than ICG solution. |
| Databáze: | OpenAIRE |
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