Visual symptoms after lung transplantation: a case of progressive multifocal leukoencephalopathy
| Autor: | H Haaxma-Reiche, Wim Timens, van der Wim Bij, J P Ouwens, W J de Boer, Erik A M Verschuuren, L H Steenhuis |
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| Rok vydání: | 2000 |
| Předmět: |
Transplantation
Pathology medicine.medical_specialty Visual acuity genetic structures business.industry Progressive multifocal leukoencephalopathy medicine.medical_treatment JC virus Autopsy medicine.disease medicine.disease_cause eye diseases Leukoencephalopathy Infectious Diseases Cerebrospinal fluid medicine Lung transplantation medicine.symptom Differential diagnosis business |
| Zdroj: | Transplant Infectious Disease. 2:29-32 |
| ISSN: | 1398-2273 |
| DOI: | 10.1034/j.1399-3062.2000.020106.x |
| Popis: | After solid organ transplantation, signs and symptoms of the central nervous system may present a diagnostic challenge. A 43-year-old patient developed a decrease in vision 15 months after bilateral lung transplantation. The initial diagnosis was a left posterior cataract, but left eye cataract extraction did not improve his vision. Seizures led to investigation of a broader differential diagnosis (cyclosporine intoxication, post-transplant lymphoproliferative disorder, infectious disease, chronic lymphatic leukemia). The clinical diagnosis of progressive multifocal leukoencephalopathy (PML) was confirmed by demonstration of JC virus in the cerebrospinal fluid and by autopsy findings. Modulation of the immunosuppressive regimen was unsuccessful. This case illustrates that decreased vision in immunocompromised patients may be the first manifestation of PML. |
| Databáze: | OpenAIRE |
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