Multiple Low-Pressure Sonications to Improve Safety of Focused-Ultrasound Induced Blood-Brain Barrier Disruption: In a 1.5-MHz Transducer Setup
| Autor: | Jin-Chung Chen, Po-Hong Hsu, Jiun-Jie Wang, Kun-Ju Lin, Hao-Li Liu |
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| Rok vydání: | 2009 |
| Předmět: |
Intracerebral hemorrhage
Materials science business.industry medicine.medical_treatment Ultrasound Blood–brain barrier medicine.disease High-intensity focused ultrasound Focused ultrasound Transducer medicine.anatomical_structure Embedded system medicine Blood-brain barrier disruption business Micro bubble Biomedical engineering |
| Zdroj: | IFMBE Proceedings ISBN: 9783540928409 |
| Popis: | Burst-mode driven high intensity focused ultrasound (HIFU) with the presence of ultrasound micro bubbles has been proven to be capable of locally and reversibly increasing the permeability of blood-brain barrier (BBB). However, the use of excessive acoustic pressure usually accompanied with intracerebral hemorrhage, which is considered a deterred side effect, especially when in applications such as drug delivery. The purpose of the current study is to provide a secure protocol using multiple low-pressure sonications, to disrupt localized BBB and preserve sonicated area without producing intracerebral hemorrhage. |
| Databáze: | OpenAIRE |
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