Production of (S)-4-chloro-3-hydroxybutyronitrile using microbial resolution

Autor:	Toshio Suzuki, Hideaki Idogaki, Naoya Kasai
Rok vydání:	1996
Předmět:	Resolution (mass spectrometry) biology Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Pseudomonas Pharmaceutical Science biology.organism_classification Biochemistry Yield (chemistry) Drug Discovery Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2581-2584
ISSN:	0960-894X
Popis:	A new production procedure of ( S )-4-chloro-3-hydroxybutyronitrile was developed using microbial resolution. The resting cells of Pseudomonas sp. OS-K-29 preferentially converted ( R )-4-chloro-3-hydroxybutyronitrile to the corresponding 1,2-diol by the dehalogenating activity so that ( S )-4-chloro-3-hydroxybutyronitrile (94.5 %ee) was obtained from the racemate in 40 % yield at the microbial resolution step.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1858c640532acaa300bf88d38827a6af https://doi.org/10.1016/0960-894x(96)00475-1 Zobrazit plný text záznamu Full Text from ScienceDirect