Inhibition of Advanced Glycation End Products Formation by Mangifera indica Leaf Extract
| Autor: | Kimihisa Itoh, Morio Iijima, Tetsuya Matsukawa, Masahiko Fumuro, Kaoru Isaki, Kohei Akai, Hideaki Matsuda, Kazuya Murata, Kohsuke Shimizu, Tomoka Yamaji, Nao Sakaguchi, Shin'ichiro Kajiyama |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
biology 010405 organic chemistry Mango leaf extract Albumin biology.organism_classification Inhibitory postsynaptic potential 01 natural sciences Mangifera indica leaf extract 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Glycation Chlorophyll Botany Food science Mangiferin human activities Green mango |
| Zdroj: | Journal of Plant Studies. 6:102 |
| ISSN: | 1927-047X 1927-0461 |
| DOI: | 10.5539/jps.v6n2p102 |
| Popis: | The purpose of this study was to examine an inhibitory effect of mango lea f extracts on advanced glycation end products (AGEs) formation and to identify these active ingredients, and also to investigate a relationship between leaves maturation and the inhibitory activity. A methanolic extract of old dark green mango leaf extract (OML-ext) exhibited an inhibitory activity of AGEs formation in nonenzymatic glycation of albumin. The inhibitory activity of OML-ext was attributable to 3-C- β - D -glucosyl-2,4,4’,6-tetrahydroxybenzophenone ( 1 ), mangiferin ( 2 ) and chlorophyll. Inhibitory effect of young dark reddish brown mango leaf extract (YDL-ext) on AGEs formation was similar to that of OML-ext. The inhibitory activity of YDL-ext was attributable to 1 and 2 , in addition, a part of the the activity of YDL-ext due to anthocyanins whose content is highest in young dark reddish brown mango leaves. Considering the amounts of leaves obtained from pruning, old dark green leaves may be a reasonable natural resource for the preparation of ingredients with inhibitory activity of AGEs formation. |
| Databáze: | OpenAIRE |
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