Preparation of Antitunror Active Vinyl Polymers Containing 5-Fluorouracil as a Component

Autor:	Shoichiro Ozaki, Takahiko Akiyama, Toshio Nagase, Nobuaki Uehara, Junji Ohnishi, Akio Hoshi
Rok vydání:	1990
Předmět:	Acrylate polymer Polymers and Plastics Radical polymerization Solution polymerization Isocyanate Vinyl polymer chemistry.chemical_compound chemistry Polymer chemistry Materials Chemistry Copolymer Organic chemistry Methyl acrylate Acrylic acid
Zdroj:	Polymer Journal. 22:689-695
ISSN:	1349-0540 0032-3896
Popis:	1-Acryloyloxyethylcarbamoyl-5-fluorouracil (1) was prepared by the reaction of 5-fluorouracil and 1-acryloyloxyethyl isocyanate. Various kinds of vinyl polymers were prepared by radical polymerizations of 1, with methyl acrylate, vinylimidazole, acrylic acid, vinylpyrrolidone, and acrylamide. Antitumor activity of these vinyl polymers was tested against L-1210 leukemia in mice. 1 had toxicity, but the homopolymer of 1 and the copolymer of 1 and methyl acrylate showed excellent antitumor activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::184e2c4a41c9d0e1d30497cea4a0a19c https://doi.org/10.1295/polymj.22.689 Zobrazit plný text záznamu