| Autor: |
Jasmin Rahesh, Arham Siddiqui, Praveen Tumula, Rahul Chandra |
| Rok vydání: |
2022 |
| Zdroj: |
The Southwest Respiratory and Critical Care Chronicles. 10:45-47 |
| ISSN: |
2325-9205 |
| Popis: |
Mixed phenotypic acute leukemia (MPAL) comprises of both lymphoid and myeloid markers or blasts in a single population. Diagnostic criteria hinges on classifications provided by identifying these lineages based on cytogenetic markers taken throughout the disease course. We describe an interesting presentation of a patient who had first presented with Acute Myeloid leukemia (AML) but 8 weeks later transformed into Early precursor T cell ALL (ETP-ALL). Cytogenetics were taken throughout the course of the cancer and confirmed the presence of a CD34 precursor cell marker. This transformation and cytogenic markers indicated a pluripotent progenitor cell origin confirming the diagnosis of MAPL. This case highlights a pluripotent progenitor origin with initial presentation as AML (myeloid clone) and later as ALL after initial partial response to AML therapy due to clonal evolution. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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