Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration
| Autor: | Nicole Weis, Andreas Weigert, Anna M. Solà, Kerstin Brecht, Bernhard Brüne, Niels Borregaard, Georgina Hotter, Eugenia Vinuesa, Michaela Jung |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Kidney
Sphingosine Sphingosine-1-phosphate receptor Regeneration (biology) Inflammation Biology medicine.disease Pathology and Forensic Medicine chemistry.chemical_compound medicine.anatomical_structure chemistry Renal physiology Immunology medicine Cancer research Sphingosine-1-phosphate medicine.symptom Reperfusion injury |
| Zdroj: | The Journal of Pathology. 225:597-608 |
| ISSN: | 0022-3417 |
| Popis: | Inflammatory reactions are initiated to eliminate pathogens, but also to promote repair of damaged tissue after acute inflammation is terminated. In this regard, macrophages play a prominent role during induction as well as resolution of inflammation and injury in various organs including the kidney. The present study describes a mechanism for renal tissue regeneration after ischaemia/reperfusion injury. Following injury, apoptotic cell-derived sphingosine-1-phosphate (S1P) or exogenously administered sphingosine analogue FTY720 activates macrophages to support the proliferation and healing of renal epithelium, once inflammatory conditions are terminated. Both suppression of inflammation and renal regeneration might require S1P receptor 3 (S1P3) signalling and downstream release of neutrophil gelatinase-associated lipocalin (NGAL/Lcn-2) from macrophages. Overall, our data point to a macrophage-dependent S1P-S1P3-Lcn-2 axis that might be beneficial for restoration of kidney function after an ischaemic insult. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text