| Popis: |
Age-related progressive loss of lung function contributes to disability and premature death. How the circadian clock regulates the development and progression of age-related lung diseases, and the underlying molecular mechanisms, are still largely unknown. The chronobiology of the lung and the role of the circadian clock in the pathophysiology of age-related lung disease will be discussed in this chapter. We describe the molecular links between the circadian clock and the specific hallmarks of aging to provide a better understanding of healthy lung aging and age-related lung disease. Furthermore, the impact of external factors in the intrinsic circadian regulation will be integrated into the complex profiling of age-related lung diseases as well as chrono-therapeutic approaches. Finally, gaps in our knowledge and future directions will be discussed. |
