Stroke with transfusions changing to hydroxyurea (SWiTCH): A phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload

Autor:	Ronald W. Helms, Rathi V. Iyer, Zora R. Rogers, Scott T. Miller, Russell E. Ware, Nicole A. Mortier, Myron A. Waclawiw, Lee Hilliard, William H. Schultz, Nancy A. Yovetich, J. Paul Scott, Ofelia A. Alvarez
Rok vydání:	2011
Předmět:	Pediatrics medicine.medical_specialty Anemia business.industry Hematology medicine.disease Sickle cell anemia law.invention Clinical trial Oncology Randomized controlled trial law Recurrent stroke Pediatrics Perinatology and Child Health medicine Chelation therapy Young adult business Stroke
Zdroj:	Pediatric Blood & Cancer. 57:1011-1017
ISSN:	1545-5009
DOI:	10.1002/pbc.23145
Popis:	Background Stroke occurs in 5–10% of children with sickle cell anemia (SCA) and has a high (>50%) risk of recurrence without therapy. Chronic monthly erythrocyte transfusions effectively prevent recurrent stroke, but their long term use is limited by serious side effects, including iron overload. An alternative to transfusion for secondary stroke prevention in SCA is needed, especially one that also improves the management of iron overload.
Databáze:	OpenAIRE
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