Acute And Subchronic Toxicity Of Anacardium occidentale Linn (Anacardiaceae) Leaves Hexane Extract In Mice
| Autor: | Leonard Tedong, Jean-François Flejou, Théophile Dimo, Emmanuel Acha Asongalem, Patrice Callard, Selestin Ndogmo Sokeng, Paul Désiré Djomeni Dzeufiet, Pierre Kamtchouing |
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| Rok vydání: | 2008 |
| Předmět: |
Creatinine
biology Traditional medicine business.industry Anacardium Renal function Anorexia biology.organism_classification medicine.disease chemistry.chemical_compound Complementary and alternative medicine chemistry Oral administration Diabetes mellitus Drug Discovery Toxicity Medicine Anacardiaceae medicine.symptom business |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines. 4 |
| ISSN: | 0189-6016 |
| DOI: | 10.4314/ajtcam.v4i2.31194 |
| Popis: | These studies focus on the toxicity leaf hexane extract of A. occidentale L (Anacardiaceae) used in Cameroon traditional medicine for the treatment of diabetes and hypertension. Previous findings on antidiabetic and anti-inflammatory have given support to the ethnopharmacological applications of the plant. After acute oral administration, it was found that doses of the extract less than 6 g/kg are not toxic. Signs of toxicity at high doses were asthenia, anorexia, diarrhoea, and syncope. The LD(50) of the extract, determined in mice of both sexes after oral administration was 16 g/kg. In the subchronic study, mice received A. occidentale at doses of 6, 10 and 14 g/kg (by oral route) for 56 days. At doses of 2, 6 and 10 g/kg of extract, repeated oral administration to mice produced a reduction in food intake, weight gain, and behavioural effects. Liver or the kidney function tests were assessed by determining serum parameters like, creatinine, transaminases, and urea. All these parameters were significantly (p |
| Databáze: | OpenAIRE |
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