Tinospora Cordifolia: A review of its immunomodulatory properties
| Autor: | Mary E D Yates, Eugene J Bruno, Charles R Yates |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
030109 nutrition & dietetics Nutrition and Dietetics Phyllanthus biology Traditional medicine Dietary supplement Terminalia Decoction 030229 sport sciences Tinospora cordifolia biology.organism_classification 03 medical and health sciences 0302 clinical medicine Nutraceutical Phytochemical Pharmacology (medical) Ethnomedicine Food Science |
| Zdroj: | Journal of Dietary Supplements. 19:271-285 |
| ISSN: | 1939-022X 1939-0211 |
| DOI: | 10.1080/19390211.2021.1873214 |
| Popis: | Emergent health threats have heightened human awareness of the need for health and wellness measures that promote resilience to disease. In addition to proper nutrition and exercise, health-conscious consumers are seeking natural-based modalities, e.g. botanical preparations, that positively impact the immune system. In Ayurvedic ethnomedicine, Tinospora cordifolia (T. cordifolia), a deciduous climbing shrub indigenous to India, has been used to historically to combat acute and chronic inflammation as well as to promote a balanced immune response. As a dietary supplement, T. cordifolia has been administered most often as a decoction either alone or in compositions containing other medicinal plant extracts of the Terminalia and Phyllanthus species. Extensive phytochemical characterization of aqueous and alcoholic extracts of different Tinospora species has identified over two hundred different phytochemicals from non-overlapping chemical classes with the most abundant being diterpenoids containing the clerodane-type skeleton. Numerous pharmacology studies have demonstrated that T. cordifolia modulates key signaling pathways related to cell proliferation, inflammation, and immunomodulation. However, rigorous dereplication studies to identify active constituents in various T. cordifolia extracts and their fractions are lacking. In this review, we will summarize the current information regarding T. cordifolia's ethnomedicinal uses, phytochemistry, pharmacological activities, and safety in order to highlight its potential as an immunomodulatory dietary supplement. |
| Databáze: | OpenAIRE |
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