Analysis of function of the glutamatergic and GABAergic mediator systems in the olfactory cortex of spontaneously hipertensive rats in vitro
| Autor: | A. Kh. Khama-Murad, A. A. Mokrushin |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
musculoskeletal
neural and ocular physiology Excitotoxicity Long-term potentiation AMPA receptor Biology Inhibitory postsynaptic potential medicine.disease_cause General Biochemistry Genetics and Molecular Biology Glutamatergic nervous system Biochemistry Postsynaptic potential medicine Excitatory postsynaptic potential General Agricultural and Biological Sciences Long-term depression Neuroscience |
| Zdroj: | Biology Bulletin. 34:376-381 |
| ISSN: | 1608-3059 1062-3590 |
| DOI: | 10.1134/s1062359007040103 |
| Popis: | The effect of persistent hypertension on neuronal activity and synaptic transmission has been studied on olfactory cortex slices of SHR rats. The profilies of focal potentials in hypertensive rats demonstrated a short duration of the 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)-propanoic acid (AMPA) component of excitatory postsynaptic potential (EPSP), a small amplitude and long duration of the N-methyl D-aspartate (NMDA) component of EPSP, and a large amplitude of the GABAB-dependent slow inhibitory postsynaptic potentials. The sensitivity of glutamate receptors responsible for the generation of AMPA- and NMDA-mediated EPSPs was low after the exposure to 1 mM L-glutamate. The amplitudes of the AMPA- and NMDA-mediated EPSPs decreased. Tetanization of slices from hypertensive rats induced a short-term potentiation followed by a depression. The data obtained indicate that persistent hypertension has depressive effects on the basic glutamatergic and GABAergic parameters of synaptic activity of neurons as well as on learning and memory. Apparently, these processes were evoked by glutamate excitotoxicity in the brain of hypertensive rats. |
| Databáze: | OpenAIRE |
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