Case Report: Primary ganglioneuroblastoma occurrence in lower thoracic spine
| Autor: | Taha Nafees, Gohar Jawad, Muhammad Khurram Zia, Saeed Mazhar, Osama Salam, Syed Zawahir Hassan, Syeda Ifra Asad, Masuma Islam |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Thoracic spine General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Neoplasm General Pharmacology Toxicology and Pharmaceutics Ganglioneuroblastoma General Immunology and Microbiology medicine.diagnostic_test biology business.industry Neural crest Magnetic resonance imaging General Medicine medicine.disease Ganglion medicine.anatomical_structure 030220 oncology & carcinogenesis Synaptophysin biology.protein Immunohistochemistry business 030217 neurology & neurosurgery |
| Zdroj: | F1000Research. 9:59 |
| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.19895.1 |
| Popis: | Ganglioneuroblastoma is a neural tissue neoplasm, which is derived from the neural crest cells. It is mostly seen in the pediatric population but is very rarely found in the lower thoracic spine. Here, we report a rare case of ganglioneuroblstoma occurrence in the lower thoracic spine. A 2.5-year-old boy presented with spinal compression symptoms and on magnetic resonance imaging, a mass was identified over T10 to L1. The tumor showed round blue cells and mature ganglion cells with hypermitotic activity. Immunohistochemical synaptophysin and neurofilament staining was positive, confirming the diagnosis. The patient showed significant improvement after surgical excision of the tumor. This is the first reported case of ganglioneuroblastoma in the lower thoracic spine that was successfully treated in Pakistan. |
| Databáze: | OpenAIRE |
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