| Autor: |
Vu Huy Hoang, Tran Danh Cuong, Le Pham Sy Cuong, Ngo Toan Anh, Chu Quang Dao, Nguyen Hai Long, Nguyen Thi Thu Huong, Nguyen Pham Duy Linh, Phan Thi Tinh, Nguyen Xuan Viet |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Tạp chí Y học Cộng đồng. 62 |
| ISSN: |
2354-0613 |
| Popis: |
Objectives: Determination of the prevalence of all chromosomal defects and its distribution in fetuses with increased nuchal translucency thickness. Methodology: This is a retrospective study among pregnant women indicated for amniocentesis by nuchal translucency above 2.5 mm and consent to the study. 2720 cases were included to the study during 6 years’ period from 2015 to 2020. All singleton pregnancies whose nuchal transluciency measurements were equal or over 2.5mm, were indicated for amniocentesis. Results: The study was consist of 2720 amniocentesis in which fetal nuchal transluciency was elevated. The median maternal age was 29.19 years old (range 17-46), and the median fetal crown-rump length was 66.9 mm (range 45– 84). The fetal karyotype was abnormal in 560 (20.6%) pregnancies. The popular chromosomal conditions were including trisomy 21(55%), trisomy 18 (11.2%), trisomy 13 (3.9%), 45, XO (2.7%). Chromosomal aberrations rate was 17.6% at maternal age of 30- 34, 34% and 50.0% at maternal age of 35- 39 and ≥ 40 respectively. Conclusion: In fetuses with increased nuchal translucency, more than a half of the chromosomal aberrations were trisomy 21 (55.0%). Structural rearrangements were 22.5%. Advanced maternal age (above 35) increases the risk of chromosomal aberrations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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