Mini-review: The structure and synthesis of proteoglycans of articular cartilage

Autor:	Christopher J. Handley, D J McQuillan, Dennis A. Lowther
Rok vydání:	1985
Předmět:	education.field_of_study biology Chemistry Cartilage Population Cell Biology Chondrocyte Cell biology carbohydrates (lipids) Extracellular matrix medicine.anatomical_structure Biochemistry Proteoglycan biology.protein Extracellular medicine education Aggrecan Intracellular
Zdroj:	Cell Biology International Reports. 9:753-782
ISSN:	0309-1651
DOI:	10.1016/0309-1651(85)90095-5
Popis:	The major proteoglycan of articular cartilage is a protein-polysaccharide of great complexity. The structure of this macromolecule is described in this article and is correlated to the function of proteoglycans within the extracellular matrix of cartilage. Chondrocytes, which comprise the cell population of cartilage, are responsible for the synthesis of proteoglycans. A description of the synthesis of proteoglycans reflects the complex nature of these macromolecules and involves a number of sites within various organelles of the chondrocyte. The pathway of proteoglycan synthesis is discussed in addition to the intracellular and extracellular events involved in the regulation of their biosynthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::17ec1b1bf13eec2431d210b1466f05e2 https://doi.org/10.1016/0309-1651(85)90095-5 Zobrazit plný text záznamu